Shailesh Date, Ph.D.
Founder and Chief Executive Officer
Laboratory for Research in Complex Systems
Univ. of Pennsylvania School of Medicine (Postdoc in Parasitology, with David Roos & Chris Stoeckert)
Univ. of Texas at Austin (Ph.D. in Mol. Bio. (Computational Bio.) with Edward Marcotte)
National Merit Scholarship, India (1996-97)
Associate Adjunct Professor, Dept. of Epidemiology & Biostatistics, UCSF
Professor (Adjunct), Biology, SF State
1. Pediatric Infectious Diseases and Public Health
I am interested pediatric infectious diseases, their spread, and the effects of "seasonal" (non life-threatening) infections on both the pediatric population and their caregivers. We hypothesize that pediatric care-giving burden is heavily underestimated, and the effects of caring for sick children have a profound effect on the workforce and the economy, particularly when considering burdens in lower socio-economic classes and traditionally disadvantaged and disfranchised groups.
2. Origins of Complexity and Information Gain in Biological Systems
The evolution of multicellular, higher order forms from a few organic molecules in primordial soup is one of the most important, and, as yet, unanswered questions in the sciences. From a thermodynamic (biophysical) systems perspective, this is a remarkable achievement; evolution appears to have found ways to completely corral and subdue entropy, while generating incredible complexity. To better understand the mechanisms behind complexity development, we have proposed a new model – an agent-based Biophysical Model of Adaptive Evolution (BMAE) – that will focus on elucidating the role played by evolutionary processes like exaptation to spur second-order phase transitions within biological systems, particularly protein interaction networks. Through this model, we will test assumptions regarding complexity that may arise from new interactions between proteins, allowing new biochemical pathways to form, which in turn lead to physiological and morphological effects. Additionally, we plan to undertake simple wet-lab experiments designed to test other key assumptions, such as function-uptake through exposure to novel protein domains, addition of interactors to existing interaction networks and the role of horizontal gene transfer in facilitating network enlargement. Our emphasis on examining physical phenomena makes our project quite distinct from other contemporary approaches. We are interested in using both quantitative and wet approaches to discover first principles of biological complexity, while also using synthetic biology approaches to modify and even “design” new systems if possible.
Morisaki JH, Smith PA, Date SV, et al. A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase. MBio. 2016 Sep 6;7(5). pii: e00412-16.
Date SV*, Modrusan Z*, Lawrence M*, et al. Global gene expression of methicillin-resistant Staphylococcus aureus USA300 during human and mouse infection. J Infect Dis. 2014 May 15;209(10):1542-50. (* equal contributors).
Date SV* and Stoeckert CJ. Computational modeling of the Plasmodium falciparum interactome reveals protein function on a genome-wide scale. Genome Res. 2006 Apr;16(4):542-9. *Corresponding author
Lee I, Date SV, Adai AT and Marcotte EM. A Probabilistic functional network of yeast genes. Science. 2004 Nov 26;306(5701):1555-8.
Adai AT, Date SV, Wieland S and Marcotte EM. LGL: Creating a Map of Protein Function with an Algorithm for Visualizing Very Large Biological Networks. JMB. 2004 Jun 25;340(1):179-90.
Date SV and Marcotte EM. Discovery of uncharacterized cellular systems by genome-wide analysis of functional linkages. Nature Biotech. 2003 Sep;21(9):1055-62.
The Boundaries of Life Initiative: Investigating the origin, evolution and bounds of life on Earth and beyond
Gordon and Betty Moore Foundation
Period: 4/2019 - 3/2022
Boundaries of Life (Phase II)
John Templeton Foundation
Period: 9/2018 - 8/2020
Role: Co-PI and Technical Lead
Modeling the intersection of evolution and physical processes to explain the origin of biological complexity
Period: 7/2020 - 6/2021