Origins of biological complexity
How did biological systems become complex in the first place? Why do some cells/systems, like in prokaryotes, remain essentially simple? Why does evolution come up with different solutions even when the underlying genetic information is conserved? Researchers at the LRC are trying to answer these questions by uniquely examining the intersection of evolutionary and physical processes through computational and experimental means. Their current focus is on protein-protein interactions, which essentially underpin nearly all biophysical and biochemical aspects of biological systems.
Life as Information!
When it comes to storing information in a cell, DNA/RNA are far from the complete story; in fact, a cell is teeming with information that is reflected in its choice of structurally relevant molecules, the organization of its ultrastructure, gradients, processes, flows and a variety of other components. Information is also gained as cells differentiate and organize into higher order structures such as tissues and organs. LRC scientists aim to study the information content of cells and higher-order structures, and also plan to explore the evolution of read-write systems, with the exciting possibility of engineering and rewiring such systems.
Info about our other projects in Public Health, Deep Knowledge Catalogs, Information Theory, etc. coming soon!